A Newly Published Controlled Study Suggests Promising Results In Antioxidant Supplementation And Adult Down Syndrome With Dementia

Miami, Florida (PRWEB) January 11, 2012 Nutri-Med Logic Corp: A two year controlled study of anti-oxidant supplementation for dementia in individuals w

newly published controlled study suggests promising results in ...

Miami, Florida (PRWEB) January 11, 2012

Nutri-Med Logic Corp: A two year controlled study of anti-oxidant supplementation for dementia in individuals with Down Syndrome, by the Department of Neurology, University of California, Irvine, suggests a strong association of seizures with cognitive decline in individuals (demented) with Down Syndrome.

Dr. Ira Lott, a past Chairman of Department of Pediatrics and Neurology as well as Associate Dean of Clinical Neuroscience at University of California, Irvine, and a principal investigator of this study has previously pointed to high levels of oxidative stress in those with Down syndrome.

Dr. Lott states that certain abnormalities in mouse model Down Syndrome are also found in human models and, further, genes implicated in Down Syndrome (chromosome 21) are associated with oxidative stress and demise of the neurons (apoptosis). Furthermore, the excessive oxidative stress may directly contribute to the pathogenesis of Alzheimer in Down Syndrome patients. (1)

Excessive free radicals and their subsequent oxidative stress ultimately may damage mitochondria (cellular energy plant) and a "damaged mitochondria" is one of the hallmarks of Alzheimer, not only in Down Syndrome patients, but also in whole.

According to Dr. Lott, anti-oxidant supplements (diets) have not produced uniform results. (1)

Nutri-Med Logic states in choosing an effective anti-oxidant supplementation, one has to, first, determine if the anti-oxidant would be capable of passing the blood-brain barrier; then, if it possesses the ability to pass the cellular membrane (fat) as well as the cytosol (liquid) in order to reach the mitochondria.

R-Alpha Lipoic acid (also known as R-Lipoic Acid) is a biologically significant (active) compound, produced by human body, that amongst its many other vital properties inactivates the lipid peroxides, reactive oxygen species and reactive nitrogen species, which cause mitochondrial dysfunction. (2)

In animal studies, R-Alpha Lipoic Acid has easily crossed the blood-brain barrier. Oral doses of 10 mg/kg of R-Alpha Lipoic Acid in rats reached peak levels in the cerebral cortex, spinal cord and peripheral nerves within 30 minutes of administration. Daily supplementation of R-Alpha Lipoic Acid reached all areas of the central / peripheral nervous system and decreased lipid peroxidation (about 50%) in the brain and sciatic nerve tissue. (3,4)

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Source : http://imentalhealth.net/mental-health-disorders/cognitive-disorders/a-newly-published-controlled-study-suggests-promising-results-in-antioxidant-supplementation-and-adult-down-syndrome-with-dementia

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